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As do other arsenicals, it induces G 2 /M cell cycle arrest and triggers apoptosis through disruption of mitochondrial functions and JNK activation and is responsible for reactive oxygen species production (Garnier et al., 2013)

Current NHS and NICE guidance emphasises lifestyle modificationincluding weight loss, dietary improvement, and increased physical activityas the cornerstone of management, with antioxidant supplementation playing at most a limited, specialist-supervised role in carefully selected patients

Similar phenotypes were observed between HMEC-1 cells and Vero cells, including defects in cell division and actin-based motility upon GSH depletion (Fig