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This condition leads to the formation of large, abnormal, and immature red blood cells and impaired DNA synthesis ( Like the condition called iron deficiency anemia, anemia related to B12 deficiency may make your skin pale due to a lack of fully-matured, healthy red blood cells in the body ( Headaches are among the most commonly reported symptoms related to B12 deficiency in both adults and kids ( A 2019 study with 140 people, half of whom experienced migraine, found that blood levels of B12 were significantly lower in the participants with migraine ( Research continues to investigate if treatment with B12 may improve migraine headache symptoms in some people ( Having low levels of B12 can cause elevated levels of a sulfur-containing amino acid called homocysteine

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Additionally, autophagy can delay or prevent apoptosis to a certain extent, protecting chondrocytes and synovial cells, but excessive autophagy may lead to autophagic cell death, further exacerbating the pathological process of OA

Results were normalized to either average SRB staining on a surrogate cell culture plate or to cell confluency measurements obtained on the Incucyte (Sartorius)