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demonstrated that it could be considered an immune target in colon cancer [49]

Contact your doctor immediately if you experience any of the following rare but serious side effects, including: Severe allergic reaction: Rash, swelling of the face, lips, tongue, or throat, severe dizziness, or trouble breathing Lung problems: Fluid in your lungs, trouble breathing, worsening of asthma Blood clots: Pain, swelling or warmth in the leg, shortness of breath, chest pain Heart attack: Chest pain or tightness, pain that radiates up your shoulder, arm, neck, or jaw Stroke: Sudden problems with vision, speech, or walking, numbness on one side of your body or face Twisting of your ovary: Sudden onset of severe abdominal pain, nausea, vomiting Ectopic pregnancy: Stomach or pelvic pain (especially on one side), neck pain, nausea and vomiting, shoulder pain, rectal pain This is not a complete list of side effects that may occur

STAT3 hyperactivation promotes cellular proliferation, survival as well as immunosuppression by promoting VEGF, IL-6, IL-10 and TGF-

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