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Conversely, H 2 O 2 /O have been shown to impair antioxidant enzymes function, thereby diminishing the cell's defenses against oxidative damage and amplifying oxidative stress [100]

Protective effects of riboflavin and selenium on brain microsomal ca 2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model

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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation