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J Clin Invest (2019) 129:435064

Extensive research indicates that NRF2 plays a pivotal role in regulating ferroptosis due to its diverse functions in iron, lipid, and amino acid metabolism (Shakya et al., 2023

10 reported a significant reduction in the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) in aqueous humor and a significant increase in aqueous protein carbonyl content, compared to control subjects