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The disruption of the vital enzymatic steps associated with glutamine utilization by glutaminase inhibitors results in reduced availability of metabolic intermediates required for nucleotide synthesis, tricarboxylic acid (TCA) cycle replenishment, and redox balance maintenance, collectively inducing metabolic stress and compromising cancer cell viability [56]

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The brain needs lots of oxygen to function optimally, which means it produces a lot of free radicals

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