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26 Because of the instability of the natural antioxidants, synthetic antioxidants have been used in stabilizing fats and oil and have been used as antioxidants in human food for many decades

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 7% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Under these circumstances, CO application induced dissociation of the haem-mediated dimers of PGRMC1 to generate a peak of monomers (Supplementary Fig