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While its overexpression is associated with the accumulation of reactive oxygen species resulting in cell death [136,137,138,139]

Unlike growth hormone or anabolic steroids, it does not drive sodium retention or fluid accumulation in clinically meaningful amounts

The majority of research was determined to be at extreme risk of bias due to inadequate description of randomisation (25%, 3/12), allocation concealment (16.67%, 2/12), description of baseline characteristics (8.33%, 1/12), blinding of caregivers/researchers (8.33%, 1/12), selective reporting of results (8.33%, 1/12) and other sources (8.33%, 1/12)

Patients also face risks of hypersensitivity reactions, gastrointestinal bleeding, ulceration, and perforation, as well as acute kidney injury, particularly in elderly