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Piperlongumine Piperlongumine (PL) is an alkaloid isolated from Piper species, commonly used in traditional medicine in particular in Asia and Latin America that in recent years has been extensively studied because of its anti-cancer potential, being able to inhibit proliferation in several cancer cell lines 107

Physiologically, endoplasmic reticulum is responsible for several cellular functions including protein biosynthesis, folding, and transport, calcium storage and gated release, and lipid biosynthesis [45]

Oxidative stress in allergic and inflammatory skin diseases