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In some instances, upon administration (e.g., intratympanic injection) of a conventional otic formulation or composition (e.g., DSP in a buffer), the concentration of a drug in the perilymph of an individual will rise sharply (C max at about 1-2 hours) and then taper off to below C min

J Proteome Res 16(3):13151326 Katt WP, Ramachandran S, Erickson JW, Cerione RA (2012) Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation

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(3) the effect of SCFAs on oxidative stress and mitochondrial damage: superoxide dismutase, catalase, glutathione, and nitric oxide (NO) all contribute to ROS production in the process of oxidative stress