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Dimethyl fumarate is currently the only Nrf2 activator with FDA approval for the treatment of multiple sclerosis but is also associated with desensitization and other side effects (Gold et al

Alves, A.C.F

That dose, adjusted for human weight, would be roughly 1,600 mg for an average adult, far exceeding any practical use by orders of magnitude

In fact, at GSH concentrations within the physiological range in red blood cells, SNO-Hb can still promote vasodilation even under oxygenated conditions (46)