Agm antidepressant effects have been reported to depend upon both imidazoline and GABA receptors, and NMDA-NO axis inhibition (and less consistently between studies, perhaps also serotonin and adrenergic receptors), suggesting a complex ketamine-like rapid antidepressant mechanism that may involve Agm/Glu co-transmission (Uzbay, 2012
So, unlike topical self-tanners that tint the outer layer of your skin and dont have any internal, systemic effects, melanotan is acting within the cells of the body just like UV radiation
Because of this, we do not ship with cold packs
Additionally, microglia-derived chemokines (e.g., CXCL9) engage CXCR3 receptors on CD8 + T cells and Th1 cells, enhancing TNF- production (Turner et al., 2007)