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Results were not blinded for analysis

Common plateau scenarios include: The circulation bottleneck: repair stalls because nutrient delivery is insufficient The remodeling bottleneck: pain improves but stability does not return The inflammation bottleneck: repair attempts are repeatedly interrupted by flare cycles The structure bottleneck: collagen forms but remains disorganized and weak GLOW is designed to support these simultaneously

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This antinociceptive profile may reflect DSIPs interaction with endogenous opioid peptide systems and/or NMDA receptor modulation at spinal cord and supraspinal pain processing sites