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Oral administration of myricetin significantly reduces Fe 2+ levels in the substantia nigra of PD rats, inhibits neuronal ferroptosis, decreases ROS production, downregulates malondialdehyde (MDA) and -synuclein (-Syn) expression, elevates GSH levels, and ameliorates motor deficits

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In vitro treatment of the retinal ganglion cell line (RGC-5) with TSA showed significant RNA transcription-dependent neurotrophic action (Schwechter et al., 2007a)

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RS supplementation significantly increased faecal butyrate and reduced faecal calprotectin concentrations in the PD group compared to baseline, whereas no changes were observed in controls supplemented with RS or in PD patients given dietary advice only [103]

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