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Further, circadian clocks disruption might also be an important factor to IR development via various factors including clock gene mutations, disturbed sleep cycles, shift work and jet lag

HIF-1 can regulate the expression of VEGF gene under hypoxic stimulation (212), which is related to the adaptation of RA synovial membrane to the hypoxic microenvironment (211)

5 Pharmacology of intranasal chelators The route of administration significantly affects the pharmacokinetics, efficacy, and toxicity of iron chelator therapy for CNS disorders

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