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Indeed, Be(2)-C cells only significantly apoptose after 72 hours of (M+D+V)/3 treatment ( Figure 4C ), allowing a broad time window to identify pathways that mediate apoptosis-associated signaling

It was found that both AOD9604 and hGH resulted in fat loss in association with increased fat oxidation as well as increased levels of glycerol (relating to lipolysis), However, an added benefit of AOD9604 was that it did not lead to hyperglycemia in the mice or reduced insulin sensitivity

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However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems