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Formation of Aminochrome and Protein Adducts Aminochrome forms adducts with proteins such as -synuclein [31], stabilizing and inducing the formation of neurotoxic protofibrils [32]

Follow-up evaluation Follow-up evaluation includes any of the previous exams completed during the initial evaluation that are required to monitor both response to and possible adverse effects from prescribed antihypertensive therapies, in addition to the assessment of any new symptoms of target organ damage and the assessment of patient adherence to therapy (Box 12-2)