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Although these conclusions appeared to be justified based on the reported experiments, it again raised the issue of questionable neutropenia experiments111,115, and the findings contradicted previous data showing that IL-1 receptor-deficient mice were not protected123, that total elimination of Kupffer cells actually enhanced APAP-induced liver injury125,126, and that TLR9120,121 and TLR3127 are important for the pathophysiology
This heterogeneity is partly genetic: mouse strains with polymorphisms in the Slc6a4 gene (encoding the 5-HT transporter) exhibit divergent responses to ethanol, with short-allele carriers showing heightened vulnerability to depression-like phenotypes
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