The expression of Nrp1 in T reg is associated with the expression of FoxP3, which suggests its role as a mediator of the immunosuppressive phenotype [143]
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Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (488), contradicting the hypothesis that ME/CFS could be caused by a clearance failure of the pathogenic microbe (99, 107)