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In stroke, the timing question is still debated, and the largest trial did not show a clear overall benefit

In models where nerves have been transected or crushed, treatment with the peptide has led to accelerated functional recovery, improved nerve conduction, and enhanced histological signs of healing

NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability