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Glutathione (GSH) levels were considerably reduced, increasing the ROS/GSH ratio, significantly decreasing the expression of the autophagy protein LC3B and related genes, and substantially increasing the expression of the caspase3 protein and apoptosis-related genes in apoptosis assays
In addition, this parameter was recorded for the study of lipid profile, considering the demonstrated role of oxidative stress, both in the induction of cardiac arrhythmias and in lipid oxidation with subsequent development of an immune response, with a pathogenic evolution towards accelerated atherosclerotic endothelial dysfunction (4)
BPC 157 in Gastrointestinal Research Models
liposome Despite Phase I clinical trials confirming the safety of polyphenolic compounds at high doses, challenges such as low bioavailability, poor absorption, rapid metabolism, and quick systemic clearance impede their clinical and preclinical applications
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