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In recent years, small molecule antagonists, antisense oligonucleotides, and monoclonal antibodies targeting GCGR have been developed and demonstrated efficacy in improving glycemic control in both rodent models of diabetes and human patients with diabetes 8,9,10,11,12,13

The IGI proposes that fluorine opyrazine treatment ameliorated -cell function in diabetic rats ( in vivo and in vivo study, they did not describe the isolation methods of the compounds

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this may be due to the nature of the condition or via the limitation of therapeutic options available to these patients [7,8,9,10,11,12]