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SAG : Animal studies show oral SAG (30 mg/kg for 8 weeks) significantly restores liver GSH, reduces GSSG (oxidized glutathione), and lowers lipid peroxidation in CCl-induced liver injury

The antioxidant action is based in many ways, such as free radical elimination, proton transfer, metallic ions binding, solitary oxygen suppressing, and serving as a trigger for removing superoxide and hydroxyl radicals (Yaacoub et al., 2023)

Thus, based on the role of oxidative stress in the pathogenesis of GO, a therapy with antioxidant agents has been proposed and a number of studies have been performed, both in vitro and in vivo , which is reviewed here

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