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This included Nfkbia , an endogenous inhibitor of the NF-B pathway (down 51%), as well as the key immunomodulatory transcription factors Rorc (down 94%) and Irf4 (down 90%)

In the lipid domain, one randomized controlled trial using high-concentration hydrogen-rich water reported modest improvements in cholesterol and glucose-related parameters in patients with metabolic syndrome (88), whereas studies using bicarbonate-rich mineral waters have reported mixed findings depending on population, water composition, and study design (90, 91)

Homocysteine metabolism The figure illustrates a biochemical pathway of homocysteine metabolism, with the two vitamin B 6 dependent enzymes highlighted

Angew Chem-Int Ed 51(36):91199122