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Data extraction was conducted by two independent reviewers using a standardized form encompassing author details, publication year, study type, employed techniques, number of patients, patient demographics (age), follow-up duration, treatment efficacy outcomes (tumor volume decrease, local pain relief using Visual Analog Scale (VAS), and local pain-free survival, referring to the period during which the patient remains free from pain after the intervention), and AEs graded following the guidelines of the Society of Interventional Radiology (SIR) [13] and the National Cancer Institute Common Terminology Criteria Adverse Events (CTCAE, version 4.0)

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Bacteriostatic water used for reconstitution should be discarded after 28 days to prevent pH shifts from bacterial growth

Results from these products are unpredictable, and side effects from contaminants are a real risk