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The farnesoid X receptor agonist GW4064 downregulated MMP-2 activity by inhibiting protein kinase C alpha (PKC) phosphorylation, an effect reversible by the PKC agonist phorbol 12-myristate 13-acetate (138)

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

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Over the last 30 years the number of diagnosed cases has increased from 0.4-0.5 to 4.0 per 1000 for autistic disorder and from 2 to 7.7-9.9 per 1000 for autism spectrum disorders [13] which is largely attributable to broadening diagnostic criteria, younger age at diagnosis and improved case ascertainment [4]