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Clinical evidence pertaining to migraines, oxidative stress, and neurogenic inflammation, along with experimental evidence of topiramates antioxidative and anti-inflammatory effects, provide strong hypothetical support for the idea that topiramate may treat migraines by blocking oxidative stress and neurogenic inflammation pathways

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As of the time of writing, both agents remain in clinical development and have not received a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA)