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All statins are administered in active hydroxy acid forms, except simvastatin and lovastatin, which require in vivo biotransformation from their lactone prodrug forms to exert pharmacological effects (Vickers et al., 1990

Folate is also important for men adequate male folate status is associated with lower rates of sperm DNA fragmentation and chromosomal abnormalities in sperm

Nonn, L., et al., The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice

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