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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration

As a research-use-only (RUO) material, GHK-CU is intended solely for analytical, experimental, and non-clinical research environments, ensuring compliance with regulatory standards and scientific rigor

Merck KGaA Germany 10.24

The percentage of the suprathreshold voxels was used as a measure reflecting global BBB leakage