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Faster absorption leads to higher peak concentrations but shorter duration

High-dose oral supplementation may be another treatment option, because consuming 1,000 g (1 mg) per day of vitamin B 12 orally should result in the absorption of about 10 g/day (1% of dose) by passive diffusion

Although the development of venous ulcers is complex, the primary mechanism involves high pressure in the leg veins, which causes fluids and molecules to leak into the surrounding tissue causing inflammation and tissue damage

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Smoday I.M., Petrovic I., Kalogjera L., Vranes H., Zizek H., Krezic I., Gojkovic S., Skorak I., Hriberski K., Brizic I., et al