Precautions: Allergic-type reactions following the injection of products containing thiamine have been reported
Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L,
peaks during dose escalation, typically mild-moderate Diarrhea -- 10-20%, usually transient Constipation -- 8-15% Vomiting -- 5-15%, more frequent at higher doses Injection site reactions -- 5-10%, mild erythema and pruritus Decreased appetite -- 5-12%, related to mechanism of action Pancreatitis -- rare but monitored (as with all GLP-1/amylin agents) Gallbladder events -- cholelithiasis reported, consistent with rapid weight loss Trial data describes dose titration as central to tolerability -- the 16-week escalation protocol substantially reduced GI adverse events
[115:32] Andrew Huberman Raise my hand, Professor Bakri