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Tesamorelin has the strongest evidence for reducing visceral abdominal fat in adults with HIV-associated lipodystrophy, while GLP-1/GIP medications such as semaglutide and tirzepatide are generally stronger options for overall weight loss

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Alogliptin (0.03% w/w in diet) decreased the body weight, expressions of TNF and IL6, abdominal fat deposition, and increased heat production in high fat diet-induced alterations in mice