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In parallel studies, FMT-pIC NPs inhibited melanoma angiogenesis by downregulating VEGF and angiopoietin-2, disrupting endothelial cell networks and synergizing with macrophage-driven immune activation to create a hostile TME for tumor survival (111)

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72 These findings suggest that subnormal ALP levels may be a useful diagnostic tool for HPP, that PLP levels may be useful in patients with a suspected diagnosis of HPP, for screening family members to detect possible heterozygotes, and to monitor response to therapy