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Polystyrene nanoplastics accelerated the amyloid aggregation of the A53T mutant, leading to increased production of glial activation biomarkers, cytokines, and reactive oxygen species in vitro , as well as disruption of mitochondrial and lysosomal membrane integrity (36)

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Within the complex, p53 TAD2 residues 47 to 54 displayed increased rigidity upon binding and consistently maintain an -helical conformation throughout the MD calculations (Fig

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