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Mouse studies suggest that biotransformation of GLR to SFN occurs in the colon (13, 21, 26), and we confirmed that the majority of SFN accumulation occurs in the colon by using multiple locations of measurement along the GI tract (13)

A systematic review analyzing multiple clinical trials confirmed that oral glutathione at doses of 250-500mg showed a significant reduction in melanin index compared to placebo over 8-12 weeks

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