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Nature 392 (6676), 569574
Oxidative stress is a potential mechanism underlying intestinal epithelial barrier dysfunction as it can induce direct epithelial cell damage and disrupt TJ and/or AJ function and structure.1215 Possible factors causing oxidative damage in the intestine of patients with cirrhosis include ingested alcohol,16 changes in intestinal microbiota,4,17,18 intestinal inflammation11,19 and disturbed microcirculation of the intestinal mucosa secondary to portal hypertension.1,20,21 In addition, systemic inflammation and oxidative stress as well as oxidative stress inducers produced in the liver, may be transferred to the intestine via blood and bile.15,22 These factors together with a decreased antioxidant status in cirrhotic patients23 may promote intestinal oxidative damage
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Research-grade 5-amino-1mq dosage protocols typically employ 50100mg daily doses administered subcutaneously, with initial titration starting at 2550mg for tolerance assessment
