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For example, CRISPR-Cas9 gene editing technology can be used to edit genes related to ROS generation and clearance, such as NQO1, p53, and NRF2, thereby regulating ROS levels [513,514,515]

Clinical studies show no significant side effects with long-term daily use

GGT hydrolyses the -glutamyl bond of glutathione or glutathione-S-conjugates and transfers the -glutamyl moiety to an acceptor molecule, often an amino acid [38]

To determine whether ETV6 accumulation contributes to EC tumorigenesis driven by FBXW7 deficiency, we generated FBXW7 KO Ishikawa and HEC-1A cells and subsequently depleted ETV6 using shRNA-mediated knockdown (Fig