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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

More than half a million people are shareholders in the Green Bay Packers and the teams former quarterback Aaron Rodgers is taking a similar fan-owned approach with his internet startup, the Online Sports Database, which seeks to build a community by crowdsourcing $1.25 million in bridge funding

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