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You can still keep exfoliants or other actives in your regimen using tretinoin

Case in point, 7 days of L-citrulline supplementation at a daily dose of 6 g significantly increase plasma citrulline, arginine, and nitrite levels, VO 2 kinetics, in response to moderate intensity (70% VO 2 peak) exercise performance [18]

From How Stuff Works: "Serious salt imbalances, like those that occur with dehydration, may lead to heart and nervous system problems that, unless they are rapidly resolved, can result in a medical emergency." That's why drinking plain old tap water is not the most effective choice when you're hungover