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For example, hypertrophic chondrocytes release matrix degradation products and pro-inflammatory mediators, which aggravate cartilage damage and trigger the proliferation of nearby synovial cells and inflammatory responses (Hunter and Bierma-Zeinstra, 2019

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So we don't know that for sure, but they've, they've shown lots and lots of good studies looking at this

Proteins in total homogenates (2040 g) or nuclear extracts (40 g) were resolved by 10% SDS-PAGE and immunoblotted using following primary antibodies: chicken polyclonal antibodies against mouse GCLM 7 and mouse ALDH1A1 60