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Bacterial native amyloid monomeric CsgA protein augmented aggregation of -synuclein proto-fibrils but did not trigger the acceleration of -synuclein monomer to its oligomeric form, as no interaction occurred between CsgA and -synuclein monomer in vitro (Sampson et al., 2020)

In humans, data from SARS and Middle East respiratory syndrome also showed that neurological injury in humans is rare, strongly suggesting that, normally, the BBB provides robust neuroprotection from viral CNS invasion in most patients 30

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The discontinuation rate due to adverse events remained remarkably low throughout