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Neurodegeneration affecting the pineal gland could be an additional factor contributing to the observed lower melatonin levels in AD patients compared to age-matched non-demented controls [175]

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10.1038/nrd3254 19 GelderblomH.VerweijJ.NooterK.SparreboomA.CremophorE

To investigate the severe liver damage and increased mortality observed in hepsin / mice during the early stages after APAP administration, we employed ultra-performance liquid chromatography-tandem mass spectrometry to measure levels of APAP-cysteine adducts in mouse liver tissue, which indirectly assesses the generation of the toxic APAP metabolite, NAPQI (Hairin et al