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CoQ10, another exogenous antioxidant reduced by FSP1, has shown limited clinical efficacy in NDDs.In a Phase III trial (NCT00740714), oral CoQ10 at 1200 or 2400 mg/day, combined with 1200 IU/day of vitamin E, did not slow PD progression, as UPDRS scores increased similarly across all groups (McGarry et al., 2017)

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Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development