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They can also be toxic in the liver, bone marrow, and spleen and cause immunogenicity by attaching to the reticuloendothelial system [13]

While current research illustrates promising benefits and a favorable safety profile, larger, longer-term studies are essential to confirm its therapeutic efficacy and optimal application

Why Timing Alone Is Insufficient Here Isotretinoin's half-life of 10 to 20 hours means meaningful plasma levels persist throughout the day regardless of dosing time [1]