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In GHRH neurons, there is an estrogen receptor ER whose deletion in mice delays female puberty, since in females a group of GHRH neurons changes their phenotype to start producing Kiss1 (a key peptide in gonadotropic regulation)

Convert vial amount to micrograms (if needed): mg 1,000 = mcg Concentration: total amount (mcg) total liquid (mL) = mcg/mL Worked example (math only) If a vial is labelled 12 mg (12,000 mcg) and you add 3 mL, the concentration is 4,000 mcg/mL

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In addition to CSCs and DTPs, oncogenic mutationsparticularly KRAS mutationsalso play a pivotal role in driving mitochondrial metabolic remodeling and promoting chemoresistance [67,68,69]