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After the third immunization, the HBV-DNA levels in the patients increased again after 10 months, proving that DNA vaccines encoding a single antigen can only transiently activate the body to produce a specific immune response and cannot exert a long-lasting effect in the body [71]

She has received speaker honoraria from Bayer, Teva, Novartis, Roche, AbbVie, Boehringer Ingelheim, and Pfizer and declares no conflicts of interest related to this study