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Nutritional cofactor treatment in mitochondrial disorders

The initial formation of lipid hydroperoxides (LOOHs) and the subsequent generation of reactive aldehydes (malondialdehyde, MDA, and 4-hydroxynonenal, 4HNE) are increased during ferroptosis due to lipid peroxidation

RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression, influencing pre-mRNA splicing, mRNA stability, and translation [12]

The hypercalcemia appears to be a direct manifestation of thyroid hormone action on bone metabolism and can lead to secondary hypoparathyroidism with reduced 1,25-dihydroxyvitamin D (440, 441), and elevated serum phosphorus secondary to increased renal resorption (438, 442)