Colegio et al
Tr em t 6 tui tr ln: Ung 1/2 vin/ngy vo bui sng hoc bui ti, trc hoc sau khi n
Under the stimulation of growth factors, PI3Ks are recruited onto the plasma membrane to catalyze the phosphorylation of the 3-hydroxy group of PIP2 to generate PIP3, which then acts as the second messenger, recruiting PDK1 and AKT proteins onto the plasma membrane to partially activate AKT by PDK1
Moreover, DIG detected a higher number of AE types across multiple SOCs, including skin and subcutaneous tissue disorders (10 PT types, SOC: 10040785), nervous system disorders (6 PT types, SOC: 10029205), hepatobiliary disorders (9 PT types, SOC: 10019805), investigations (8 PT types, SOC: 10022891), infections and infestations (5 PT types, SOC: 10021881), metabolism and nutrition disorders (4 PT types, SOC: 10027433), musculoskeletal and connective tissue disorders (5 PT types, SOC: 10028395), cardiac disorders (4 PT types, SOC: 10007541), renal and urinary disorders (3 PT types, SOC: 10038359), blood and lymphatic system disorders (1 PT type, SOC: 10005329), eye disorders (3 PT types, SOC: 10015919), immune system disorders (3 PT types, SOC: 10021428), and vascular disorders (1 PT type, SOC: 10047065) compared to sICIs
