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Whether triggered by bacteria, parasites, or food allergies, gut mast cell activation can contribute to digestive symptoms such as heartburn, nausea, vomiting, constipation, and diarrhea

SS-14 is a tetradecapeptide that is formed after cleavage by endoproteases of the precursor between amino acids 101 and 102, while SS-28 corresponds to the sequence of the SS-14 form with an N-terminal extension of 14 amino acids [24] (Figure 3)

On the other hand, independent proteins importing pathways of PTS have also been reported (Kim and Hettema, 2015)

25 A nerve biopsy of the first known patient with the ACOX1 N237S mutation revealed a loss of Schwann cells