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As a first step, the relationship between prenatal air pollution exposure, as measured by average ( ave PM 2.5 ) and maximal ( max PM 2.5 ) PM 2.5 exposure during gestation, and these four indices of mitochondrial respiration are investigated, particularly with respect to NDR

By combining them, researchers can study a two-pronged approach to controlling the inflammatory cascade, potentially creating an optimal environment for tissue regeneration to begin

Downstream genes of Nrf2 include NAD(P)H quinone oxidoreductase 1, HO-1, solute carrier family 7 membrane 11 (SLC7A11/xCT), NAD(P)H quinone oxidoreductase 1, thioredoxin 1, phase II detoxifying enzymes (e.g., GSH S-transferase, UDP-glucuronosyltransferase, GPX4, GSH reductase, and glutamate-cysteine ligase subunits

Lung viral titers were evaluated in a subset of animals on D3 and D6